Collagen

Collagen

Collagen

Nationwide Pharmacies Ltd have partnered with Medicare Europe to bring you the best quality Collagen products available in Europe.

All of our Collagen products are produced in a state of the art factory in Germany which is your guarantee that you are getting the very best product available. This page is dedicated to providing you with the clinical evidence that the products you are buying from us are not only of the highest of quality but are clinicaly proven to provide the very best results.

Collagen products fall into four categories, Collagen for beautiful healthy skin, Collagen for healthy joints, Collagen for pain relief and Collagen to improve hair growth.

If you know all about the benefits of Collagen CLICK HERE TO BUY If you dont  please take a few minutes to read the clinical facts about Collagen before you decide which products to purchase.

What is Collagen

Collagen is extremely important were our skin is concerned it provides support, firmness, suppleness and hydration. Collagen is also responsible for the continual production of new skin cells. So if you want healthy supple skin with a youthful glow then you need plenty of Collagen in your system. Unfortunately after the age of 25 the natural Collagen in our system begins to reduce resulting in the aging process. We begin to see wrinkles and blemishes forming, our skin starts to lose its suppleness it becomes dry and starts to thin, these of course are all of the signs of aging.

That’s the bad news over, now here is the good news. Collagen is a simple protein made up of amino acids. During the past ten years there has been lots of scientific research into how the skin ages in particular research has shown that the major difference between aged and youthful skin is the amount of Collagen in the dermis which is the inner structural layer of the skin that supports the skins outer surface which is called the epidermis.

In aged skin the amount of Collagen in the dermis is diminished resulting in a breakdown of the dermis which in turn impacts on the outer skin causing sagging, wrinkles and lack of hydration. The big question is how do we prevent this from happening? Research shows that a good way of increasing the amount of Collagen in the dermis is to ingest Marine Collagen Peptides. Our Collagen Extra ® Marine contains the most extensively researched Collagen peptides available in the market today. Collagen Extra® marine is a unique formula combining Extra strength marine Collagen protein and Hyaluronic acid with the addition of Vitamins C, B complex and Magnesium. Each Collagen Extra® marine 25ml dose contains 8,000mg of Peptan ® F the highest quality Marine Collagen available.

Clinical studies have shown that by drinking Collagen Extra ® Marine you will increase the amount of collagen in the dermis which in turn will help to reverse all of the signs of aging by increasing the density of fibroblasts these are the cells that rebuild connective skin tissue improving the suppleness of your skin as well as hydrating it.

An added benefit of drinking Collagen Extra ® Marine is it stimulates the body’s own natural collagen production. When the body senses Collagen Peptides in the blood stream, it stimulates the proliferation of fibroblasts reinforcing the body’s natural collagen production. Taken on a daily basis, it will start to rebuild your Collagen levels which will result in a much more youthful appearance.

 Click Here To Buy Collagen Extra ® Marine

LIQUID EXTRACTS Vs. CAPSULES/TABLETS

  • The body does not need to break down a liquid extract, allowing more of the medicinal properties to be absorbed into the system. This makes an extract much more powerful than a capsule or tablet.
  • When using capsules or tablets, the body must first extract or break down the medicinal properties of the herb to put them in liquid form in the stomach.
  • Liquid extracts take 1-4 minutes to assimilate.
  • Capsules or tablets (pills) can take from 20-30 minutes just to break down, before the body can even start to assimilate them.
  • The body uses 98% of our liquid extracts.
  • The body only utilizes approximately 39-53% of capsules or tablets. Guess where the remainder ends up?
  • In order for any nutrient to reach the cells of the body, it must first be suspended in a solution. Or in other words it must be liquid. As a rule, the nearer a herbal preparation approaches the liquid form, the quicker and more completely it will assimilate and take effect in your body.

Why Take Liquid Extracts Over Capsules or Tablets?

Medical studies have shown that liquid extracts have faster absorption rates; higher optimization rates and is more easily digestible. Liquids may have a big advantage over pills when it comes to swallowing. Most people, especially the elderly and young children, tend to have more difficulty swallowing some pills. Generally, supplements in liquid form are much more readily broken down and absorbed. Additionally, it has been shown that liquids are more completely and quickly absorbed than most capsules and pills.

In fact, the Physician’s Desk Reference states that 85-90% of nutrients in liquid supplements are absorbed in 22 to 30 seconds.

Compare this to hours it takes for the nutrients in pills to be absorbed by the body. Moreover, it has been demonstrated that only 10%-20% of the nutrients in pills actually are absorbed. The National Advisory Board state that 100 mg consumed in tablet form translates into a concentration of only 8.3 mg or 8.3% in the blood. A pilot study evaluating the bioavailability and absorption rates of two vitamin B-12 preparations in normal human subjects, demonstrated that absorption rate was significantly increased when dosing was in a liquid rather than solid form. Liquid medicine is the preferred method of delivery in hospitals from emergency rooms to patient care because of the immediate benefits for the patient. While there is nothing wrong with a capsule or tablet, there are proven findings that show a liquid extract to be more powerful, beneficial and fast acting.

What Are the Benefits To A Liquid Extract?

One of the primary benefits of using liquid herbal extracts is that they do not require digestion. You don’t need to extract what is medicinal from the plant cellulose before it can be absorbed because it’s already been done for you.

The body does not need to break down a liquid extract, allowing more of the medicinal properties to be absorbed into the system. This makes liquid extract much more powerful than a capsule or tablet.

When using capsules or tablets, the body must first extract or break down the medicinal properties of the herb to put them in liquid form in the stomach.

Liquid extracts take 1-4 minutes to assimilate.

Capsules or tablets (pills) can take from 20-30 minutes just to break down, before the body can even start to assimilate them.

Studies have shown that the body uses 98% of our liquid extracts. The body only utilizes approximately 39-53% of capsules or tablets.

In order for any nutrient to reach the cells of the body, the nutrient must first be suspended in a solution. Or in other words it must be liquid. As a rule, the nearer a herbal preparation approaches the liquid form, the quicker and more completely it will assimilate and take effect in your body.

Your body assimilates extracts fast

Extracts can be assimilated into the body in 1 to 4 minutes. Capsules or tablets (pills) can take from 20 to 30 minutes just to break down, before the body can even start to assimilate them.

Extracts are even more powerful!

It could take 20 capsules to equal a daily dose of 1? teaspoons of our herbal extract.

Click Here To Buy Liquid Collagen

THE SCIENCE ON COLLAGEN  ® EXTRA 

Collagen peptides the key to smoother skin 

Fine lines and wrinkles are a key indicator of age and as such, wrinkle prevention is the primary aim of many consumers. A 12-week study conducted by Dermscan in France demonstrated that consumption of the Peptan ® collagen peptides contributes to a significant decrease in the number of microrelief furrows by 26%.  The trial also showed that Peptan ® F collagen peptides can help prevent deep wrinkle formation and increase skin suppleness by 19%. 

Anti-ageing hydration effect 

Similarly in Japan, 33 women aged between 40 and 59 took part in an 8-week clinical study. Cutaneous hydration measurements were performed in this trial with a Corneometer® CM 825 to record the collagen peptides moisturising effect.  At the end of the trial, the Corneometer measurement found an increase in skin hydration of 28% for participants who had ingested collagen peptides. No increase was observed in the placebo group. The administration of Peptan® collagen peptides led to a direct increase in skin hydration in almost two thirds of the participants, demonstrating that a daily oral intake of Peptan® F collagen peptides can significantly improve skin dryness and its associated signs.

 Pie Chart

91% of group volunteers increased skin hydration after 8 weeks
28% skin hydration increase 

Skin restructuring in just one month 

Collagen Extra ® marine works from the inside out to reverse the ageing process

  •   Cosderma 2012, clinical data, 106 women (publication in press)
  • Skin restructuring occurred in just one month
  • Confocal Laser & echography analysis of the deeper layers of dermis showed significant differences after taking Peptan ® F collagen peptides
  • Fragmentation decrease of 30% (restructuring of skin) Collagen density increase of 9% (boosting of skin)

Bar chart 

In the latest study done by Cosderma in France, 106 women took part in a clinical trial to assess the effectiveness of Peptan® F collagen peptides.  At the end of the 12-week study, a collagen fragmentation decrease of 31% was reported in participants who received Peptan® F with obvious results after just one month. No change was observed in the placebo group. By decreasing collagen fragmentation and increasing collagen density, Peptan® F  lead to visible improvements in skin structure, firmness and elasticity after 1-3 months, boosting the collagen network and thus promoting visible anti-ageing effects on the skin. This restructuring of the skin is key to the understanding of how Peptan® F can boost the collagen network and promote younger looking skin.

Collagen Extra® marine a Healthy Foundation

The Collagen peptides used in Collagen Extra® marine is an award winning example of an effective collagen peptide ingredient. Offering a unique combination of amino acids not found in other protein sources, Collagen Extra® Marine is derived from natural origins of fish grade collagen halal /kosher peptides.

image

The main structural element of the skin, collagen is largely responsible for its characteristic properties, such as firmness and tonicity. The most abundant protein in the body, collagen’s role is to maintain the structure and resistance of the skin’s tissues, creating a network which anchors the layers of the skin and forms a support base for components such as elastin, to maintain skin elasticity and hyaluronic acid to lock in moisture. Collagen fibres, constructed within fibroblast cells, are responsible for the maintenance and resistance of the skin tissues. The presence of collagen peptides regulates the activity of fibroblasts in the skin and stimulates the production of both collagen, and hyaluronic acid which is important for skin hydration.

As we age, the production of new collagen fibres declines as the collagen synthesis by fibroblasts decreases. Collagen is also hindered by its own aging process. With age, collagen becomes more and more cross-linked and fragmented. That makes the skin tougher and limits the protein’s ability to bind large qualities of water, making the skin appear dry, dehydrated and old. Smooth, firm and younger-looking skin requires optimum levels of well-organised collagen fibres to ensure that  it retains its elasticity, firmness as well as its moisture-binding capacity. Research has shown that exogenous collagen peptides may act to trigger the synthesis of new collagen fibres by stimulating fibroblast cells.

Shona Wilkinson 

Shona Wilkinson Head Nutritionist at the NutriCentre London

“I particularly like Collagen Extra® as it is in liquid form. This helps increase the absorption of the nutrients. It is also beneficial due to its high amounts of hyaluronic acid.”

“Overall, this is an excellent supplement and one I would be happy to recommend.”

Active ingredients Collagen Extra® marine 250ml  

Collagen Extra® marine. Liquid food supplement with Collagen, Hyaluronic Acid, Vitamins and Minerals.

Nutritional facts per 25 ml daily intake:

Nutritional facts

Sugar Free – Gluten Free – Lactose Free – No artificial dyes- Fat Free

Collagen Extra® Marine is derived from natural origins of fish grade collagen halal /kosher peptides. Collagen Extra® Marine is manufactured in Germany for Medicare Europe Ltd. The production process follows the guidelines of ISO: 9001:2008 and Good Manufacturing Practice, GMP regulated by the German drugs agency.

Click Here To Buy Collagen Extra ® Marine 

THE SCIENCE ON COLLAGEN MSM PLUS®

 How does Collagen MSM Plus® work?

  • Clinicaly proven Collagen peptides can be used to prevent the degradation of cartilage and thus to prevent discomfort and joint pain while maintaining collagen levels inside the cartilage. Collagen peptides used in Collagen MSM Plus® restore Bone Mineral Density to a normal level and maintain lean muscle mass.
  • MSM reduces fast inflammation that is causing pain in the joints and helps with the natural production of collagen.  Latest research has shown that the MSM helps relieve pain, especially in cases of osteoarthritis, rheumatoid arthritis, muscular pain and tendinitis
  • Vitamin D3 is nesecary for healthy bones as it regulates our body’s ability to absorb calcium.
  • Vitamin B12 helps the nervous system. Vitamin B6 strengthens the immune system and helps the body break down proteins. Vitamin C contributes to better absorptionof the ingredients and the natural production of collagen.
  • Glucosamine can help to restore cartilage while chondroitin can may help with joint hydration.

Science of Collagen and MSM

Active ingredients Collagen MSM Plus® 500ml
Liquid Food supplement Nutritional facts per daily dose 25ml
Collagen MSM Plus® Liquid food supplement with Collagen, MSM, Glucosamine, Chondroitin, Vitamins D3, B12, B6 and Vitamin C.

Sugar Free- Fat free – Gluten Free – Lactose Free – No artificial dyes Collagen MSM Plus® is derived from natural origins of bovine grade collagen halal /kosher peptides.
Directions: Take (25ml) daily, before sleep or as directed by your doctor or pharmacist. Do not exceed the recommended daily dose.

Storage conditions: Keep in a cool dry place. Keep out of the reach of children. CAUTION: Not for use by people with allergies to shellfish products. Dietary supplements should not be taken as a substitute of a varied diet. Women who are pregnant or planning a pregnancy should consult their doctor before taking dietary supplements.

Collagen MSM PLUS® is manufactured in Germany for Medicare Europe Ltd. According to ISO: 9001:2008 and GMP (Good Manufacturing Practice)

The science behind Collagen MSM Plus®

Collagen MSM Plus® and Joint Health – Osteoarthritis

Osteoarthritis (OA) involves degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness and locking.

  • Aging and high impact/load on joints can cause wear and tear on joint cartilageBone chart
  • Collagen makes up 70-95% of joint cartilage
  • Maintaining collagen levels inside cartilage is important to prevent OA

Proven effectiveness on knee Joints- Clinical study 2013 double blind, placebo controlled with specific collagen peptides used in Collagen MSM Plus®.

  • 100 participants, oral intake, Collagen peptides powder drink.
  • Collagen peptides 8 g/day or placebo(maltodextrin) 8 g/day
  • Inclusion criteria:- Complained of knee joint pain or joint discomfort- X-ray for diagnostic, classification: 0-III level – 40 to 70 years
  • 6 months period. Joint health assessed at time 0, 3 and 6 months
  • WOMAC: standard assessment/questionnaire, measures 5 items for pain (score range 0–20), 2 for stiffness (score range 0–8), 17 for functional limitation (score range 0–68) Lysholm: knee scoring method for joint movement, higher score = better knee function. Supplements WOMAC

Specific Collagen peptides used in Collagen MSM Plus® reduce joint pain and improve joint function

After just 3 months of specific Collagen peptides intake, the patients reported significant improvements: Reduced joint pain – improved joint flexibility and better overall joint functionality

Results by Shanghai 6th people hospital (Jiang et al. 2013 (in press)

Chart

Collagen MSM Plus® and Bone health- Osteopenia and Osteoporosis

More than 30% of all postmenopausal women develop Osteoporosis

Osteoporosis has four major consequences on the bone:

  • Bone mineral density (BMD) is reduced, which implies an increased risk of fractures.
  • Imbalance between bone resorption and bone formation
  • Amount and variety of proteins in bone is altered
  • Bone micro-architecture is deteriorating.
  • Osteopenia is the pre-stage to Osteoporosis

Normal Bone        Osteoporotic bone

               Normal Bone                                  Osteoporotic bone

Collagen peptides used in Collagen MSM Plus® restore Bone Mineral Density to a normal level

In vivo studies – results- Ovariectomized mice were used to simulate low bone mass density:  osteopenia

The measures show restoration of the bone mineral density value close to the level of the control group (which was not ovariectomized).

Same study demonstrated additional results of specific collagen peptides to:

  • increase bone solidity
  • increase bone size

BMD Increase

Increase of Bone Mineral Density (BMD) of the mice, in the control group (Control), the ovariectomized group fed without collagen peptides (Ovx), and the ovariectomized group fed with collagen peptides (Ovx + Collagen Peptides) after 12weeks. Groups with different letters indicate significant difference (p<0.05) a indicates a higher mean than b.

Collagen MSM Plus® and Muscle health – Sarcopenia (Loss of muscle with age)

A sufficient intake of proteins is very important to maintain a correct muscle mass. 20-30 g/day of high quality protein per meal recommended
The RDI for protein is 0.8g/kg of body weight/day for healthy adults and 1g/kg of body weight/day for elderly people. With age, diet is often too low in protein
Sarcopenia affects 30 % of 60+ years and 50 % of 80+ years
Results by Hays et al. (2009), showed that a supplement with collagen peptides maintained a better nitrogen balance than whey protein, suggesting its better suited to maintain lean muscle mass in in elderly women. Hays, N.P., Kim, H., Wells, A.M., Kajkenova, O. and Evans, W.J. 2009. J. Am. Diet.

Protein deficiency concern- changes in body mass

After the age of 30 the body composition starts to change. There is a reduction of 3 to 8% in lean muscle mass each decade.
The reduction can be more than 50% loss of tissue in those over 80 years of age.
Proteins are the major building blocks of muscles.

The intake of proteins is often decreasing in the elderly (low appetite etc.), even though the required amount is increasing

Illustration by Innova market insights, 2012

Innova market insights

The positive effect on joint cells with specific collagen peptides used in Collagen MSM Plus® formula 

Results of the 2011 study confirm the positive effect of specific collagen peptides on joint cells (chondrocytes). A dose of 10g of collagen peptides per day [1] has demonstrated a positive effect on joint pain reduction. The integrity of articular cartilage is dependent on the maintenance of the extracellular matrix, a process controlled by the joint cells, the chondrocytes. The objective of the present study with a cell culture model was to investigate the effect of collagen peptides used in Collagen MSM Plus® on the main components of the extracellular matrix of the cartilage: aggrecan and type II collagen. 

Introduction: Osteoarthritis (OA) is the most common form of arthritis which causes major disability worldwide. OA is characterized by cartilage destruction resulting in joint space narrowing and loss of function (figure 1). The result of ongoing cartilage destruction is irreversible damage to the extracellular matrix (ECM) of cartilage with ultimate loss of joint function [2]. Chondrocytes, the only cell type in cartilage, are the versatile regulators of cartilage equilibrium. Traumatic cartilage injury leads to an irreversible cartilage loss since differentiated chondrocytes do not divide and hence do not compensate for these defects [3]. There are no long-term effective treatments for OA.

Normal Knee comparison

The purpose of this study was to assess the effects of specific collagen peptides on the gene expression of 2 major constituents of the extracellular matrix of the cartilage: aggrecan [4] and type II collagen.

Assessment of the collagen peptide effects on cartilage specific gene expression

Cells were seeded and cell growth was measured until 8 days (figure 2). At the different end points mRNAs (see glossary) were extracted from the chondrocytes. The concentration of total mRNA was measured by optical density. Gene expression was then measured by quantitative PCR (qPCR, see glossary).

The expression of the cartilage extracellular matrix specific genes, aggrecan, collagen type II, was measured. The expression of the cartilage extracellular matrix specific genes, aggrecan, collagen type II, was measured.

Treatments comparison

1 Methods

The tests have been carried out by Atlantic Bone Screen Laboratory, Nantes, France (ABS).

Chondrocytes were collected from articular cartilage of 4-week-old male rats. Specific collagen peptides of bovine origin were used at 3 concentrations 0.01, 0.1 and 1 mg/mL. Ibuprofen at 25µg/ml was used as a positive reference item as it is a nonsteroidal anti-inflammatory drug (NSAID).

All the experiments have been done 3 times and the results are averages of 3 measurements

Results Effect of collagen peptides used in Collagen MSM Plus® on cartilage specific gene expression
Collagen peptides at 0.1 or 1 mg/mL concentrations over 8 days significantly enhanced the expression of aggrecan and type II collagen mRNA (fi gure 3). These results demonstrate that collagen peptides in collagen MSM Plus® specifically enhanced the chondrocyte gene expression of the cartilage extra cellular matrix components.

Results

3 Conclusion

After 8 days of treatment, collagen peptides at concentrations of 0.1 and 1 mg/mL enhanced significantly the expression of cartilage specific markers: aggrecan and type II collagen.

In this study, collagen peptides used in Collagen MSM Plus® formula have a similar effect on joint cells as Ibuprofen, a usual medication against inflammation.

These data confirm that specific collagen peptides used in Collagen MSM Plus® may prevent cartilage matrix degradation by increasing the production of aggrecan and type II collagen, in line with previous studies. The data also strengthen the hypothesis that collagen peptides may be recognized as a signal of cartilage degradation by chondrocytes which therefore activate the synthesis of aggrecan and type II collagen as a response.

These results show that collagen peptides used in Collagen MSM Plus® may be used to prevent the degradation of cartilage and thus to prevent discomfort and joint pain due to this degradation.

Glossary:

Aggrecan: the major proteoglycan of the articular cartilage, i.e. a protein modified with large carbohydrates. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure that endows the cartilage with load-bearing properties.  mRNA : Messenger RNA, is a molecule encoding a chemical «blueprint» for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis.  qPCR : quantitative Polymerase Chain Reaction, is a laboratory technique used to amplify and simultaneously quantify a targeted DNA or RNA molecule.

References

[1]:  Benito-Ruiz P.,  Camacho-Zambrano M.M., Carrillo-Arcentales J.N., Mestanza-Peralta M.A., Vallejo-Flores C.A., Vargas-Lopez S.V., Villacis-Tamayo R.A. and Zurita-Gavilanes L.A. 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International journal of food sciences and nutrition, 12:1-15.  [2]: Sofat N. Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int J ExpPathol. 2009 Oct; 90(5): 463-79. [3]: Schulze-Tanzil G. Activation and dedifferentiation of chondrocytes: implications in cartilage injury and repair. Ann Anat. 2009 Oct; 191(4): 325-38.  [4]: Kiani C, Chen L., Wu Y.J., Yee J. A., Yang B.B. Structure and function of aggrecan. Cell Research 2002; 12(1):19-32.  [5]: Oesser S,  Seifert J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res. 2003 Mar;           311(3): 393-9.

MSM “THE ULTIMATE HEALTH ALLY”

Article on Collagen MSM Plus ® regarding its main ingredient MSM by M.Sc. Pharmacist George Manios

MSM (methyl sulfonyl methane or dimethyl sulfone) is an organic sulfur compound with high bioavailability and crucial for many functions of the human body. Fresh fruit, vegetables, meat, seafood and dairy products are the main natural sources of MSM. Unfortunately a large amount of it is destroyed by washing, steaming and baking foods. Poor diet and modern lifestyle also decrease the levels of MSM in our bodies.

According to scientific research and clinical studies that have been conducted over the last thirty years in various universities and research centers around the world, MSM has shown to have strong antioxidant, anti-inflammatory, analgesic and detoxifying properties. In cases of osteoarthritis taking 500mg MSM daily for three months, provides analgesic and antiinflammatory action and contributes to joint health. According to a double – blind clinical study, the results are accelerated when combining with the administration of glucosamine sulfate, significantly improving the quality of life of the patient. The MSM helps to combat the back and neckpain, it is important to tissue regeneration and is used to promote healthy joints and cartilage. It relaxes the muscles doing it useful in rehabilitation of people who have suffered sports injuries. It is also ideal as a natural treatment of tendinitis and tennis elbow.  MSM contributes to the production of elastin, collagen and keratin of a substance that is essential for the health of hair and nails. It enhances the mucosa of the digestive tract and the urinary tract, helping in some cases of constipation and providing natural antiparasitic activity, demonstrating that the MSM (organic sulfur) is the ultimate health ally. Our body uses MSM in synergy with vitamin C to create new, healthy cells. Without proper levels of MSM, our bodies are unable to produce good and healthy cells resulting in problems such as loss of flexibility, wrinkles, varicose veins, dry skin, digestive disorders, joint problems and more. Every year we discover more miraculous properties of the MSM and many universities and research centers focus on the development and study of its properties. Let’s start now looking for more natural ways to deal withthe most common lifelimitingdiseases and let’s not forget that nature is our ally.

References • Randomized, double – blind, parallel placebo – controlled study of oral glucosamine, Methylsulfonylmethane and their combination in osteoarthritis. PMID: 17516722 • Pharmacokinetics and distribution of 35S methylsulfonylmethane following oral administration to rats. PMID: 17263509 • Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. 2003 jan-feb: 23 (IA): 453 – 8 • Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. NCT01188213 PMID 21709034 PMCID 3141601 • Effect of methylsulfonylmethane on paraquat – induced acute lung and liver injury in mice. PMID 23595869 • Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride – induced acute liver injury in rats. PMID 23591777 • MSM enhances GH signaling via the jak2/STAT56 pathway in osteoblast – like cells and osteoblast differentiation through the activation of STAT56 in MSCs. PMID 23071812 PMC 3469535 PMID 23013531 PMCID 3507661

Collagen MSM Plus® clinically researched collagen peptides offer multiple benefits for healthy aging

Collagen MSM Plus

 Collagen MSM Plus® helps maintain mobility as we age 

Medicare Europe Ltd. Is the brand owner and trademark holder of several premium ranges of nutritional supplements.  Our brands have obtained regulatory approvals in many countries and today are marketed in the UK, Germany, Belgium, Holland, Luxemburg, Greece, Australia, Singapore and soon in 9 Asian countries. Our premium formulas are made in Germany and distributed from the UK. 

Our Liquid Nutritional supplements are unique compositions of high potency, clinically tested, made of premium certified natural ingredients sourced in the EU. Our liquid lines are formulated using specific molecular weight of active ingredients in liquid form, creating unique compositions that have higher absorption and bioavailability. Our quality standards are guided by the German Drugs Agency and our products come with a health certificate regulated by the German Health authorities. 

The production line facility in Germany specializes in the production of liquid nutritional supplements since the late 1960’s. The product research, development and quality control are guided by internationally acknowledged experts in medicine, organic chemistry, pharmaceutical technology, botany and nutrition. 

A central part of the production is quality control. The production process follows the strict guidelines of ISO: 9001: 2008 and GMP regulated by the German drugs agency. 

Medicare continues its efforts to ensure the quality and safety of its products with the infamous Fresenius SGS laboratories. SGS is the world’s leading inspection, verification, testing and certifications company. SGS ISTITUT FRESENIUS has a strong reputation among manufacturers, consumers and retailers operating in Germany since 1920. 

“Our mission is to Improve life quality by creating premium formulas that really work” Medicare Europe

Click Here To Buy Collagen MSM Plus®


THE SCIENCE ON MAX HAIR

HOW DOES COLLAGEN MAX HAIR™ WORK?

Collagen Max Hair™ has been scientifically formulated to provide a complete spectrum of nutrients including the highest quality marine Collagen, Hyaluronic Acid, L-Cysteine, Biotin, Vitamins B complex, Vitamin C and Zinc which contribute to the maintenance of normal hair. Collagen Max Hair™ contains clinically proven Peptan® collagen peptides derived from fish. It’s bio-active nutrients are delivered via the blood stream directly to the hair roots for maximum benefit.

max hair

 

 

 

 

 Collagen Max Hair™ is an advanced formula of bio-active nutrients based on the latest scientific research. It has been formulated with specific nutrients including      Collagen, L-Cysteine, Biotin, and Zinc which contribute to the maintenance of normal hair. 

 Collagen Max Hair™ delivers its benefits via the bloodstream directly to the roots.



HAIR GROWTH CYCLE

Hair growth cycle

 

 

 The changes occurring at different stages of our lives, as well as poor diet, hair styling and lifestyle, can all impact the health of our hair.

 

Having a healthy head of hair begins with the proper nutritional building blocks. The hair follicle itself is a highly active factory and its requirements for oxygen, energy and protein synthesis must be met to maintain healthy hair.

 

 


Collagen MAX HAIR™ active ingredients 

 Active Ingredients

In the latest study done by Cosderma in France, 106 women took part in a clinical trial to assess the effectiveness of Peptan® F collagen peptides

Collagen Max Hair™ works from the inside to reverse the aging process

Cosderma 2012, clinical data, 106 women (publication in press)

Skin restructuring occurred in just one month Confocal Laser & echography analysis of the deeper layers of dermis showed significant differences after taking Peptan ® collagen peptides Fragmentation decrease (restructuring of skin) Collagen density increase (boosting of skin)

Cosderma study

Abstract

Hautarzt. 1989 Aug;40 (8):490-5.

[Low dosage retinol and L-cystine combination improve alopecia of the diffuse type following long-term oral administration].

[Article in German] Hertel H1, Gollnick H, Matthies C, Baumann I, Orfanos CE

In a pilot study (I) the efficacy of a new combination therapy for hair loss of the diffuse type was tested in 36 patients, followed by a double blind study with 47 patients. The daily dosage was 18,000 IE retinol, 70 mg L-cystine and 7000 mg gelatin.

The clinical efficacy was evaluated by standard methods, such as the preparation of trichograms and measurement of the hair density before and after treatment. The pilot study demonstrated a significant improvement, with reduction of the telogen rate by 8.3%, an increase of the anagen rate by 11%, and an increase of the hair density by 6.9%.

In the double blind study (II) the trichogram showed a significant decrease of the telogen rate by 13.5% compared with pathological baseline values. There was no change in the placebo group. The lowered anagen rate of 47.2% was improved by 8%, whereas the mean value in the placebo group decreased from 47.7% to 39.9%. In addition, the percentage of dysplastic anagen hairs improved by 7.4%, as against further impairment with an increase of 26% in the placebo group. During oral therapy no systemic side-effects were detected.

We conclude that long-term oral therapy with high doses of L-cystine and gelatin in combination with vitamin A may have beneficial effects on diffuse hair loss. Ref: US National Library of Medicine http://www.ncbi.nlm.nih.gov/pubmed/2676911

 Click Here To Buy  Collagen Max Hair™

THE SCIENCE OF LIPOTRIM

Collagen Lipotrim™ peptides are more satiating than other proteins

Smiling plate

A study was performed on 24 subjects to compare the effects of breakfasts containing different proteins on subsequent satiety and energy intake.

People having consumed a 25 % Hydrolyzed Collagen breakfast (HC) or Hydrolyzed Collagen with tryptophan had a reduced energy intake at the following lunch of about 20%, which was related to ≈ 40 % reduction in appetite (compared to people having consumed breakfast with casein, soy or whey proteins).

Collagen Peptides

Collagen Lipotrim™ prevents from gaining weight – compared to a standard dairy protein

Yellow pepper

Experiments have been conducted with Lipotrim™’s main ingredient Peptan® at the Laboratory of Physiology and Ingestive Behavior of INRA-AgroParisTech in Paris, France.

French study

Veldhorst et al. 2009. A breakfast with alpha-lactalbumin, gelatin, or gelatine + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey or whey-GMP. Clinical nutrition, 28: 147-155.

Collagen Lipotrim™ The Ultimate fitness formula

Fitness

Lipotrim™ collagen peptides – Bioactive proteins

Lipotrim™ contains specific collagen peptides with very specific amino acid composition that give the unique bioactive properties of Lipotrim™. Compared to other proteins Lipotrim™’s protein peptan® contains high levels of the amino acids Gly, Hyp, Pro, Ala and Arg providing specific health benefits not found with other protein sources

Amino acids

Collagen Lipotrim™

Human body

The ultimate composition of amino acids for human nutrition

Collagen Lipotrim™ provides one of the highest nutritional values in comparison with any other known food protein or diet product in the market. 90% can be absorbed within 30 minutes due to its liquid form and amino acid composition.

Lose weight without losing muscle

Collagen Lipotrim™ is extremely effective in low-calorie diets, as it facilitates weight loss without losing lean body mass. In fact 1 daily dose of 10gr of Collagen Lipotrim™ can build body protein equivalent to that obtained from about 400gr of meat or fish with just 35 calories. Collagen Lipotrim™ can:

  • Tame hunger – Assist with weight loss
  • Strengthen the tissue
  • Prevent from gaining weight in conjunction with physical exercise.

Not enough protein

Collagen Lipotrm™ can be effective as a diet supplement for those with a poor diet, as a result of medical and psychological conditions such anorexia, bulimia or convalescence, anaemia etc. Collagen Lipotrim™

  • Due to its liquid form and special amino acid combination, can be absorbed in minutes providing total protein synthesis and minimizing nitrogen waste production.
  • Collagen Lipotrim™ is ideal for patients with difficulties in swallowing pills.

Optimising Sport Performance

 As a diet supplement, Collagen Lipotrim™ is effective for those involved in sporting activities, because 99% of its amino acids act as precursors of protein synthesis.

Collagen Lipotrim™

  • maximizes muscular strength, resistance and volume
  • minimizes the recovery period after training

Collagen Lipotrim™ Protecting connective tissues–added benefits for Sports people

Study over a 2 year period, 1,150 athletes participated. German sports clinic ‘Saluto’

(source: Wienecke, 2011) Used supplement with collagen peptides enriched with BCAA+arginine

Study result:

  • Reduced injury rate by 52-67 %
  • Tendon support by collagen peptides

Demonstrated by Minaguchi et al. 2005

Reduced injury rates

Collagen is the main structural component of all connective tissues Tendons are important as they connect muscle to the bone Tendons are made of collagen type 1 fibers and bundles of muscle cells.

Active ingredients Collagen Lipotrim™

Nutritional facts per dose 10ml / 3-4 times daily

INGREDIENTS DOSE UNIT R.D.A
Active ingredients  10ml    
Lipotrim™ Bovine collagen peptides 2500 Mg **
L-Leucine 200 Mg **
L-Lysine 140 Mg **
L-Valine 160 Mg  
L-Isoleucine 150 Mg  
L-Threonine 110 Mg  
L-Phenylalanine 130 mg  
L-Methionine 70 mg  
L-Tryptophan 40 mg  
Vitamin C 40 mg  
Vitamin B6 0.7 mg  
Vitamin A 0.4 mg  
Selenium 0.025 mg  
Vitamin B12 0.00125 mg  

** RDA not established

Food Supplement
Packing: PET 250ml,
Flavour: Strawberry, vanilla
Take 10 ml 3-4 time a day 1 hr before meals
Expiry: 24-36 months

Collagen Lipotrim™ is manufactured in Germany for Medicare Europe Ltd

A central part of the production is quality control. The production process follows the guidelines of ISO: 9001:2008 and Good Manufacturing Practice, GMP regulated by the German drugs agency.

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